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1994-08-09
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Document 0016
DOCN M9480016
TI A quantitative and cartographic study of retinal microvasculopathy in
acquired immunodeficiency syndrome.
DT 9410
AU Glasgow BJ; Weisberger AK; Jules Stein Eye Institute, Los Angeles, CA
90024.
SO Am J Ophthalmol. 1994 Jul 15;118(1):46-56. Unique Identifier : AIDSLINE
MED/94295622
AB We quantified the retinal microvascular abnormalities in 57 eyes from
autopsy patients with the acquired immunodeficiency syndrome (AIDS) and
in 24 eyes from gender- and age-matched control subjects. We related
retinal vascular changes to the topography of cytomegalovirus retinitis.
Analysis of retinal trypsin digests revealed more vascular attenuation
(P = .005), increased ratio of endothelial cells to pericytes (P =
.001), and more microaneurysms (P = .02) in eyes of AIDS patients
without cytomegalovirus retinitis than in those of control subjects.
Cytomegalovirus retinitis was frequently bilateral, extensive, and
distributed along blood vessels. Peripheral retinitis was more frequent
than macular infection. Lymphocytes aggregated focally in arterioles,
venules, and capillaries leading to areas infected with cytomegalovirus.
Acquired immunodeficiency syndrome microvasculopathy occurs in the
absence of cytomegalovirus retinitis and is not accounted for by
immunosuppression alone. The location and character of these vascular
changes in AIDS indicate an ischemic pathogenesis. In AIDS patients with
cytomegalovirus retinitis, the vascular changes are more profound and
include capillary destruction.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS AIDS-Related
Opportunistic Infections/PATHOLOGY Capillaries/PATHOLOGY
Cytomegalovirus Retinitis/ETIOLOGY/PATHOLOGY Endothelium,
Vascular/PATHOLOGY Female Human Male Retinal
Diseases/COMPLICATIONS/PATHOLOGY Retinal Vessels/*PATHOLOGY Support,
Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).